코웰메디 Cowellmedi

Achieving Cell-to-cell Communication

Uniform Micro Surface Geometry and Maximized BIC for Accelerated Osseointegration

Long-lasting surface achieved with special technology, eliminating the need for additional processes such as UV and Plasma in the clinic

Unlike other implant surfaces, does not use titanium oxide but rather a biocompatible material that is sandblasted for a human-friendly surface

BMP optimized for implant placement

Strong surface stability that withstands up to 120Ncm of force

Maximized contact area between alveolar bone and implant

Comparison of SEM Images of SLA Surface Treated Implants Sold Domestically

Surface treatment images observed in electron microscopy images magnified 5,000 times from the upper part of the implant
Products from Company A, Company B, and Company C show insufficient acid etching patterns in deeper areas, with surfaces created by sandblasting appearing in some parts
On the surface of Cowellmedi INNO implants, the acid etching pattern appears uniformly, indicating a significantly high degree of completion of INNO SLA surface acid etching

A Company

B Company

Company C

Cowellmedi

Comparison of Domestic SLA Surface Treatment 3D Roughness Measurement Results

The average surface roughness value ranges from 1.07 to 3.11μm, and in the case of Cowellmedi INNO implants, the surface roughness is evenly distributed across the unit area, with the calculated average roughness value being 1.92μm.

A Company

B Company

Company C

Cowellmedi

Contact Angle Measurement Results for Physiological Saline

Increased energy facilitates better attachment of bone cells, enabling faster osseointegration

After Standard SLA Treatment

Increased Surface Activation

Blood Friendly

Surface Component Inspection (X-ray Photoelectron Spectroscopy, XPS) Comparison

Quantitative analysis of surface components shows that all products have approximately 30% carbon, 47% oxygen, 16% titanium, and 4% silicon
Cowellmedi INNO SLA consists only of carbon (C1s), oxygen (O1s), and titanium (Ti2p) components, with the main component of the alkaline cleaning solution, sodium hydroxide (NaOH), combining with silicon (Si) to form water-soluble Na2SiO2(OH)2·4H2O (water glass), removing other components

Sample	C1s	O1s	Ti2p	Si2p	M1s
Company A	34.12	45.05	15.11	5.24	0.47
Company B	31.84	46.49	15.22	4.87	1.57
Company C	32.19	47.58	17.58	2.65	N.D
Cowellmedi	27.19	50.81	17.61	N.D	N.D

Comparison of Extracts Using Combustion Ion Chromatography

Similar ions were detected in all products, but they are safe for the human body due to their harmless nature and quantity
In the case of Cowellmedi INNO SLA, no components other than NO3- were detected. SO42- and Cl- ions, which are used for heated acid etching by alkaline cleaning, form water-soluble salts Na2SO4 and NaCl and are completely removed.
No components that hinder bone regeneration were detected in both surface and extract components, indicating that the cleaning process is very well executed.Extract from Dr. Lee Dae-hee's research paper (published in June and August 2012 in Dentopline / KDM) -

Sam ple	F-	CI-	NO2-	SO42-	Br-	NO3-	PO43-
Company A	N.D	0.024	0.027	0.002	N.D	0.031	N.D
Company B	N.D	0.027	0.019	0.002	N.D	0.030	N.D
Company C	N.D	0.071	0.020	0.002	N.D	0.023	N.D
Cowellmedi	N.D	N.D	N.D	N.D	N.D	N.D	N.D

For Medical Professionals