세포를 자극하는 ‘코웰BMP’
코웰BMP는 고급형 뼈이식재입니다.
코웰BMP성장인자는 유전자 재조합 기술로 만든 단백질로
잇몸에 주입 시 잇몸뼈를 단단하게 생성하고 빠른 치유를 돕습니다.
‘코웰BMP’ 주의사항
1. 시술 후 일시적으로 붓기가 생길 수 있습니다.
2. 구강 내 감염이 있는 부위에는 사용될 수 없습니다.
3. 이미 rhBMP-2가 체내에 존재하는 미성년자에게는 권장하지 않습니다.
4. 임신 또는 수유 중이거나 임신 계획이 있으신 분에게는 권장하지 않습니다.
5. 면역력이 결핍된 환자로 방사선 요법, 화학요법 또는 스테로이드 요법이 필요한 면역력이
결핍 된 분에게는 권장하지 않습니다.
‘코웰BMP’ 임상 효과 논문
1. Analysis of hydrolyzable polyethylene glycol hydrogels and deproteinized bone mineral as delivery systems for glycosylated and non-glycosylated bone morphogenetic protein-2.
Acta Biomater. 2012 Jan;8(1):116-23.
2. Effects of rhBMP-2 Coating Tricalcium Phosphate on Socket Preservation in Dog Extraction Socket.
Tissue Engineering and Regenerative Medicine, Vol. 5, No. 4~6, pp 637-642 (2008)
3. Effects of Polycaprolactone-Tricalcium Phosphate, Recombinant Human Bone Morphogenetic Protein-2 and Dog Mesenchymal Stem Cells on Bone Formation: Pilot Study in Dogs.
Yonsei Med J 50(6): 825-831,(2009)
4. The induction of bone formation in rat calvarial defects and subcutaneous tissues by recombinant human BMP-2, produced in Escherichia coli.
Biomaterials 31 (2010) 3512–3519
5. Alveolar ridge augmentation using anodized implants coated with Escherichia coli–derived recombinant human bone morphogenetic protein 2.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. (2011) Jul;112(1):42-9
6. Bone formation of Escherichia coli expressed rhBMP-2 on absorbable collagen block in rat calvarial defects.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111:298-305
7. Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia coli–derived recombinant human bone morphogenetic protein 2 in rat calvarial defects.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112:298-306.
8. Induction of bone formation by Escherichia coli- expressed recombinant human bone morphogenetic protein-2 using block-type macroporous biphasic calcium phosphate in orthotopic and ectopic rat models.
J Periodontal Res. (2011) Dec; 46(6):682-90.
9. Enhanced adipogenic differentiation and reduced collagen synthesis induced by human periodontal ligament stem cells might underlie the negative effect of recombinant human bone morphogenetic protein-2 on periodontal regeneration.
J Periodontal Res (2011); 46: 193–203
10. The Effects of rhBMP-2 Injection at Distraction Osteogenesis of Rats’ Tibia.
Tissue Engineering and Regenerative Medicine, Vol. 8, No. 2, pp 158-163 (2011).
11. Discontinuous Release of Bone Morphogenetic Protein-2 Loaded Within Interconnected Pores of Honeycomb-Like Polycaprolactone Scaffold Promotes Bone Healing in a Large Bone Defect of Rabbit Ulna.
Tissue Eng Part A. 2011 Oct;17(19-20):2389-97.v
12. The effect of immobilization of heparin and bone morphogenic protein-2 to bovine bone substitute on osteoblast-like cell’s function.
J Adv Prosthodont 2011; 3:145-51
13. Multicenter, randomized clinical trial on the efficacy and safety of Escherichia coli-derived rhBMP-2 with β-Tricalcium phosphate and hydroxyapatite in human extraction sockets.
J Adv Prosthodont 2011; 4:178-182
14. Effects of Anodized Implants Coated With Escherichia coli-Derived Recombinant Human Bone Morphogenetic Protein-2 on Osseointegration in Rabbits.
Tissue Engineering and Regenerative Medicine, Vol. 8, No. 1, pp 62-68 (2011)
15. Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of concept study.
J Periodontal Implant Sci 2012; 42:136-143
16. Effects of anodized implants coated with Escherichia coli-derived rhBMP-2 in beagle dogs. Int.
J. Oral Maxillofac. Surg. 2012; 41: 1577–1584.
17. Bone formation of middle ear cavity using biphasic calcium phosphate lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 using animal model.
International Journal of Pediatric Otorhinolaryngology 77 (2013) 1430–1433
18. Bone formation and remodeling of three different dental implant surfaces with Escherichia coli-derived recombinant human bone morphogenetic protein 2 in a rabbit model.
Int J Oral Maxillofac Implants. 2013; 28(2):424-30
19. Recombinant Human Bone Morphogenetic Protein-2 Stimulates the Osteogenic Potential of the Schneiderian Membrane: A Histometric Analysis in Rabbits.
Tissue Eng Part A. 2013 Sep;19(17-18):1994-2004
20. The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant.
Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:e24-e31.
21. Sinus augmentation using BMP-2 in a bovine hydroxyapatite/collagen carrier in dogs.
J Clin Periodontol 2014; 41: 86–93.
22. Low-Dose Recombinant Human Bone Morphogenetic Protein-2 to Enhance the Osteogenic Potential of the Schneiderian Membrane in the Early Healing Phase: In Vitro and In Vivo Studies.
J Oral Maxillofac Surg 72:1480-1494, 2014
23. Prospective randomized, controlled trial of sinus grafting using Escherichiacoli-produced rhBMP-2 with a biphasic calcium phosphate carrier compared to deproteinized bovine bone.
Clin Oral Implants Res. 2015 Dec;26(12):1361-8.
24. Controlled release of BMP-2 using a heparin-conjugated carrier system reduces in vivo adipose tissue formation.
J Biomed Mater Res A. 2015 Feb;103(2):545-54.
25. The efficacy of BMP-2 preloaded on bone substitute or hydrogel for bone regeneration at peri-implant defects in dogs.
Clin Oral Implants Res. 2015 Dec;26(12):1456-65.
26. Effect of rhBMP-2 Immobilized Anorganic Bovine Bone Matrix on Bone Regeneration.
Int. J. Mol. Sci. 2015, 16, 16034-16052.
27. Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study.
Biomed Res Int. 2015; 2015:459393.
28. Comparison of collagen membrane and bone substitute as a carrier for rhBMP-2 in lateral onlay graft.
Clin Oral Implants Res. 2015;26(1):e13-9.
29. Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration.
Materials 2016, 9, 954
30. Source and Carrier Effect on the Bioactivity of BMP Bio-Implants.
Master of Science 2013. Sylvie Di Lullo 2013, Faculty of Dentistry, University of Toronto
31. Soft and hard tissue changes when socket preservation using rhBMP-2, PRP and Non-Resorbable dPTFE membrane.
Dental implant Journal: Vol. 3, May, 2014
32. The effect of rhBMP-2 bonegraft on infrabony defects.
Dental implant Journal: Vol. 3, May, 2014
BMP-2가 세포에
BMP-2가 부착된 세포가
뼈 재생을 위한 영양공급
단단한 골조직으로
