Tissue Engineering Institute for Growth Factors
It is the goal of COWELLMEDI Tissue Engineering Institute for Growth Factors
to develop technology that can completely restore the
nature-look gingiva.
As the first South Korean Dental Implant enterprise that grafted Recombinant Human Bone
Morphogenetic Protein(rhBMP-2) to dental implant, COWELLMEDI has been leading the era
of next-generation bio-convergence implants.
What is COWELLMEDI rhBMP-2?Recombinant Human Bone Morphogenetic Protein-2
What happens when the stem cells and BMP-2 are combined?
Osteoinductive
BMP-2 is human growth factor(protein) which pediatric can self-produce but adults are disabled to produce by themselves.
Therefore, when genetically engineered rhBMP-2 is injected into defective gingiva tissue and bone,
it simulates stem cells in the body and quickly grows into bone and gum tissue.
The procedure of rhBMP-2 growth factor how to grow into bone
Stem cells BMP-2 attached
grows into bone cells.
BMP-2 attached stem cells
grows into bone cells.
Nutrition and blood vessels are
formed for bone regeneration.
The strong bone
tissue is formed.
Research papers on CowellBMP
- Effects of rhBMP-2 coating Tricalcium phosphate on socket preservation in dog extraction socket Tissue Engineering and regenerative Medicine V5,No4~6 (2008)
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Effects of polycaprolactone-Tricalcium phosphate, recombinant Human Bone Morphogenetic Protein-2 and
Dog Mesenchymal stem cells on bone formation: pilot study in dogs Yonsei Med J 50(6), 2009 -
Alveolar ridge augmentation using anodized implants coated with E coli –derived recombinant human bone
morphogenetic protein-2 Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112(1),2011 -
The induction of bone formation in rat calvarial defects and subcutaneous tissue by recombinant human
BMP-2, produced in Escherichia coli Biomaterials 31, 2010 -
Induction of bone formation by Escherichia coli-expressed recombinant human bone morphogenetic
protein-2 using block-type macrophorous biphasic calcium phosphate in orthotopic and ectopic rat model J periodontol Res2011 - Morphometric analysis on bone formation effect of β-TCP and rhBMP-2 in rabbit mandible J Korean Assoc Oral Maxillofac Surg (2010)
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Bone formation of Escherichia coli expressed rhBMP-2 on absorbable collagen block in rat calvarial
defects Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011) -
Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia
coli–erived recombinant human bone morphogenetic protein 2 in rat calvarial
defects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011) -
Analysis of hydrolyzable polyethylene glycol hydrogels and deproteinized bone mineral as delivery
systems for glycosylated and non-glycosylated bone morphogenetic protein-2 Acta Biomaterialia (2011) -
Enhanced adipogenic differentiation and reduced collagen synthesis induced by human periodontal
ligament stem cells might underlie the negative effect of recombinant human bone morphogenetic
protein-2 on periodontal regeneration J Periodont Res (2011)