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组织生物工学

组织生物工程 LAB

完美地维持并复原人类的牙龈的技术,
是柯威尔迈迪 rhBMP-2 研究所的目标。

在韩国企业中最先开发再组合第2型人类骨形成蛋白质(rhBMP-2), 并与种植体结合，引领着生物融合种植体的新一代。

  • 양질의 뼈 재생
  • 세균 감염 방지
  • 안정성 입증

柯威尔迈迪 rhBMP-2是?再组合第2型人类骨形成蛋白质成长因子

干细胞与BMP-2接触的话?

Osteoinductive(骨诱导性)

BMP-2是人体内的成长因子（蛋白质）,小儿可自己生成，但成人不可自己生成。将以遗传工程技术做成的rhBMP-2注入到
缺损的牙龈及骨头里，可刺激人体内的干细胞，以促进骨骼和牙龈组织的成长。

rhBMP-2 成长因子形成骨的过程

  • BMP-2附着到干细胞
  • 附着BMP-2的干细胞成长为骨细胞。
  • 形成骨再生所需的营养供应及血管。
  • 替换成结实的骨组织.

使用CowellBMP的研究论文

  • Effects of rhBMP-2 coating Tricalcium phosphate on socket preservation in dog extraction socket Tissue Engineering and regenerative Medicine V5,No4~6 (2008)
  • Effects of polycaprolactone-Tricalcium phosphate, recombinant Human Bone Morphogenetic Protein-2 and
    Dog Mesenchymal stem cells on bone formation: pilot study in dogs     Yonsei Med J 50(6), 2009
  • Alveolar ridge augmentation using anodized implants coated with E coli –derived recombinant human bone
    morphogenetic protein-2     Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112(1),2011
  • The induction of bone formation in rat calvarial defects and subcutaneous tissue by recombinant human
    BMP-2, produced in Escherichia coli     Biomaterials 31, 2010
  • Induction of bone formation by Escherichia coli-expressed recombinant human bone morphogenetic
    protein-2 using block-type macrophorous biphasic calcium phosphate in orthotopic and ectopic rat model     J periodontol Res2011
  • Morphometric analysis on bone formation effect of β-TCP and rhBMP-2 in rabbit mandible J Korean Assoc Oral Maxillofac Surg (2010)
  • Bone formation of Escherichia coli expressed rhBMP-2 on absorbable collagen block in rat calvarial
    defects     Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011)
  • Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia
    coli–erived recombinant human bone morphogenetic protein 2 in rat calvarial
    defects.     Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011)
  • Analysis of hydrolyzable polyethylene glycol hydrogels and deproteinized bone mineral as delivery
    systems for glycosylated and non-glycosylated bone morphogenetic protein-2     Acta Biomaterialia (2011)
  • Enhanced adipogenic differentiation and reduced collagen synthesis induced by human periodontal
    ligament stem cells might underlie the negative effect of recombinant human bone morphogenetic
    protein-2 on periodontal regeneration     J Periodont Res (2011)